Ssa Antibody Levels

Ss a ro antibodies occur in patients with several different connective tissue diseases including sjogren syndrome an autoimmune disease that involves primarily the salivary and lachrymal glands up to 90 of cases. Anti ssa levels may be elevated in the following conditions. The antibodies can be detected years before symptoms of sle surface making them an effective diagnostic tool.

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Both anti ssa and anti ssa are usually absent in secondary sjögren s syndrome.

Ssa antibody levels.

The ssa antibody is usually found with the ssb antibody which means there is typically an anti ssb blood test ordered with the anti ssa test. When anti ssa levels are elevated in sle it is often in antinuclear antibody ana negative lupus. In the book the lupus book. Ss a ro is an extractable nuclear antigen ena composed of protein antigens of 52 kd and 60 kd combined with cytoplasmic rna species.

Systemic lupus erythematous sle. Lupus erythematosus le 40 60 of. The ssa antibody can also show up in a blood test that is unrelated to sjögren s syndrome. Some people with autoimmune diseases may get a negative test result for ana but positive for other antibodies.

Sjögren s antibody ss b is present only if sjögren s antibody ss a is also detected. The presence of both antibodies ss a and ss b strengthen the diagnosis of sjögren s syndrome and conveys prognostic information. A positive ana test means that you have high levels of ana in your blood. Anti ro ssa antibodies are found in 40 90 of patients with systematic lupus erythematosus sle.

In patients with sle high levels of anti ro ssa are correlated with elevated levels of ifn α. A guide for patients and their families author daniel wallace explains that ssa plays a role in systemic lupus and categorizes it as a cell surface component. It is not a specific enough test to determine a definitive diagnosis in a majority of patients but it can be used with other tools and tests to determine if lupus is present. Sjogren s antibodies ss a ss b sjögren s antibodies ss b is detected in approximately 15 of patients with sjögren s syndrome.

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