Ssa Antibody Reference Range

60 70 of cases systemic lupus erythematosus sle.

Ssa antibody reference range.

Ss a ro ss b la rnp and sm are autoantigens commonly referred to as extractable nuclear antigens ena. Antibodies to ena are common in patients with connective tissue diseases systemic rheumatic diseases. Sjogren s antibodies ss a ss b sjögren s antibodies ss b is detected in approximately 15 of patients with sjögren s syndrome. A positive anti ro result is revealed and known by a speckled appearance under immune fluorescence with ultraviolet light.

The reference range of anti ro antibodies is negative. Ss a ro antibodies are associated with childhood le neonatal le and with congenital heart block in infants born to mothers with le 1 2 ss a ro antibodies have also been reported to be associated with features of extraglandular inflammation in patients with le including vasculitis purpura cytopenias and adenopathy. Ss a ro antibodies occur in patients with several different connective tissue. The presence of both antibodies ss a and ss b strengthen the diagnosis of sjögren s syndrome and conveys prognostic information.

Anti ro antibodies also known as anti ssa antibodies are associated with sjögren syndrome. Sjögren s antibody ss b is present only if sjögren s antibody ss a is also detected. This has been termed antiphospholipid antibody syndrome. Anti ro levels may be elevated in the following conditions.

Ss b la is composed of a 48 kd protein combined with rna species. Lupus erythematosus le 40 60 of. 25 of cases both anti ro ssa and. Ss b la antibodies are found primarily in patients with sjogren syndrome or le where they occur with frequencies of approximately 60 and 15 respectively 1 2 ss b la antibodies occur only infrequently in the absence of ss a ro antibodies.

Patients with ss a may also have antibodies to cardiolipin lupus anticoagulant and clinical thromboses. The reference range of anti ro antibodies is negative. Ss a ro is composed of protein antigens of 52 kd and 60 kd combined with cytoplasmic rna species. Ss a ro antibodies occur in patients with several different connective tissue diseases including sjogren syndrome an autoimmune disease that involves primarily the salivary and lachrymal glands up to 90 of cases.